鼻アレルギー鼻粘膜好塩基性細胞の研究 VI 好塩基球と肥はん細胞の関係
STUDIES OF BASOPHILIC CELLS IN NASAL ALLERGY

HIROKUNI OHTSUKA, MINORU OKUDA, YOSHIKIO SAKAGUCHI
1984 Nippon Jibiinkoka Gakkai Kaiho  
Basophils and mast cells appear in the nasal mucosal surface of nasal allergic patients and play an important role in nasal symptom. In order to investigate the relationship between basophil and mast cell in the nasal mucosal surface, we studied changing of these cells in numbers after nasal provocation by putting on the mucosal surface with Japanese cedar powder into the nasal cavities of Japanese cedar pollinosis patients. After nasal secretions were smeared on slideglass by blowing and
more » ... y blowing and specimens were taken from the nasal mucosal surface by scraping with small curette and stained by Hansel's solution, under a light microscopy, we regarded the cells those were small and contained the larger but a fewer granules and had the lobulated nucleus as the basophils, and the other typed cells those were larger and contained the smaller but more granules and had mononucleus as the mast cells. As a result, the number of blood basophils decreased 1 hour later and increased again 2 hours later after the provocation, but basophils in the scraping specimens on the mucosal surface and nasal secretion remarkably increased, however, the mast cells almost not changed. From these results, it is considered that the basophils emigrated in the nasal mucosal surface from blood vessel as the complemental role for the mast cells.
doi:10.3950/jibiinkoka.87.141 fatcat:emqntjwexngd7nhsfjx76wrc3m