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The cancer stem cell (CSC) model suggests that high levels of CSCs within a tumor are associated with poor prognosis. The aim of this study was to investigate the expression of the stem cell marker CD133 in clear cell renal cell carcinoma (ccRCC), and its prognostic significance. The expression of CD133 was examined in 140 cases of ccRCC using immunohistochemistry. Ki-67 and Oct-4 were doubleimmunostained with CD133 to evaluate the proliferative activity and the stemness of CD133-expressingdoi:10.3892/ol.2011.368 fatcat:gvttupxjf5hrzm7z2ywfr7w2jm