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Induction of cancer cell-specific death via MMP2 promoterdependent Bax expression
Controlled gene expression in specific cells is a valuable tool for gene therapy. We attempted to determine whether the lentivirus-mediated Tet-On inducible system could be applied to cancer gene therapy. In order to select the genes that induce cancer cell death, we compared the ability of the known pro-apoptotreic genes, Bax and tBid, and a cell cycle inhibitor, p21cip1/waf1, and determined that Bax was the most effective. For the cancer cell-specific expression of rtTA2 S -M2, we tested thedoi:10.5483/bmbrep.2009.42.4.217 pmid:19403045 fatcat:mxvezh6rgjexniwekv2gawnr7m