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The spatial distribution of atrophy in neurodegenerative diseases suggests that brain connectivity mediates disease propagation. Different descriptors of the connectivity graph potentially relate to different underlying mechanisms of propagation. Previous approaches for evaluating the influence of connectivity on neurodegeneration consider each descriptor in isolation and match predictions against late-stage atrophy patterns. We introduce the notion of a topological profile — a characteristicdoi:10.7554/elife.49298 pmid:31793876 pmcid:PMC6922631 fatcat:yyornpu2jnhcnm53t5eavctnje