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Differences in topological progression profile among neurodegenerative diseases from imaging data
2019
eLife
The spatial distribution of atrophy in neurodegenerative diseases suggests that brain connectivity mediates disease propagation. Different descriptors of the connectivity graph potentially relate to different underlying mechanisms of propagation. Previous approaches for evaluating the influence of connectivity on neurodegeneration consider each descriptor in isolation and match predictions against late-stage atrophy patterns. We introduce the notion of a topological profile — a characteristic
doi:10.7554/elife.49298
pmid:31793876
pmcid:PMC6922631
fatcat:yyornpu2jnhcnm53t5eavctnje