Identification of drug-specific pathways based on gene expression data: application to drug induced lung injury

Ioannis N. Melas, Theodore Sakellaropoulos, Francesco Iorio, Leonidas G. Alexopoulos, Wei-Yin Loh, Douglas A. Lauffenburger, Julio Saez-Rodriguez, Jane P. F. Bai
2015 Integrative Biology  
An Integer Linear Programming (ILP) formulation is introduced to model the modes of action of lung toxic drugs based on gene expression data and prior knowledge of protein connectivity.
doi:10.1039/c4ib00294f pmid:25932872 fatcat:6nre2o35czblnnh5pa2yha5ncq