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Staring, a Novel E3 Ubiquitin-Protein Ligase That Targets Syntaxin 1 for Degradation
Syntaxin 1 is an essential component of the neurotransmitter release machinery, and regulation of syntaxin 1 expression levels is thought to contribute to the mechanism underlying learning and memory. However, the molecular events that control the degradation of syntaxin 1 remain undefined. Here we report the identification and characterization of a novel RING finger protein, Staring, that interacts with syntaxin 1. Staring is expressed throughout the brain, where it exists in both cytosolicdoi:10.17615/1b31-j215 fatcat:yekjczmkofhczg6tsgb47h5dne