STUDY OF ECHOCARDIOGRAPHY IN THALASSEMIA (MAJOR/INTERMEDIA) PATIENTS AT TERTIARY CARE CENTER

Usha B K, Stalin S, Ravi Chandran T, Gnanasambandam S
2018 Indian Journal of Child Health  
Objective: The objective of this study is to study the cardiovascular complications and to establish the role of echocardiography (ECHO) screening in beta thalassemia major (TM) and intermedia patients, aged 2-12 years, receiving one or more transfusions per month for 2 or more years. Methods: A cross-sectional study was done at tertiary care center from June 2015 to November 2015. Hemoglobin, serum ferritin, and 2D ECHO were done before the blood transfusion. Results: Male preponderance was
more » ... reponderance was seen with a ratio of 1.7:1. 87% (n=47) had TM and remaining had thalassemia intermedia (TI). Serum ferritin in TM was >1000 ng/ml in 80.9% (n=38) of cases and <1000 ng/ml in 19% (n=9) of cases. Serum ferritin in TI was above 1000 ng/ml in 42.8% (n=3) and <1000 ng/ml in 57.14% (n=4) of cases. 64% (n=35) had cardiomegaly in X-ray. 2D Echo showed increased LV mass in 71.1% (n=27) of cases and normal LV mass in 28.9% (n=11) of cases. Pulmonary hypertension was seen in 21.2% (n=10) of cases of TM and 42% (n=3) of cases with TI. Conclusion: ECHO combined with electrocardiogram should be used for regular periodic monitoring of transfusion-dependent thalassemia patients. Usha et al. Study of echocardiography in thalassemia (major/intermedia) patients at tertiary care center Vol 5 | Issue 8 | August 2018 Indian J Child Health 534 Study of echocardiography in thalassemia (major/intermedia) patients at tertiary care center Vol 5 | Issue 8 | August 2018 Indian J Child Health 535
doi:10.32677/ijch.2018.v05.i08.006 fatcat:hdfnrrcxy5azrk5dqczgwyvooi