We study the general gaugings of N=2 Maxwell-Einstein supergravity theories (MESGT) in five dimensions, extending and generalizing previous work. The global symmetries of these theories are of the form SU(2)_R X G, where SU(2)_R is the R-symmetry group of the N=2 Poincare superalgebra and G is the group of isometries of the scalar manifold that extend to symmetries of the full action. We first gauge a subgroup K of G by turning some of the vector fields into gauge fields of K while dualizing

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... remaining vector fields into tensor fields transforming in a non-trivial representation of K. Surprisingly, we find that the presence of tensor fields transforming non-trivially under the Yang-Mills gauge group leads to the introduction of a potential which does not admit an AdS ground state. Next we give the simultaneous gauging of the U(1)_R subgroup of SU(2)_R and a subgroup K of G in the presence of K-charged tensor multiplets. The potential introduced by the simultaneous gauging is the sum of the potentials introduced by gauging K and U(1)_R separately. We present a list of possible gauge groups K and the corresponding representations of tensor fields. For the exceptional supergravity we find that one can gauge the SO^*(6) subgroup of the isometry group E_6(-26) of the scalar manifold if one dualizes 12 of the vector fields to tensor fields just as in the gauged N=8 supergravity.