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The aim was to characterize the effects of magnesium sulfate, using i.v. bolus and local administration, using intrinsic signal imaging, and on electrocorticographic activity during the induction and propagation of spreading depolarizations in the gyrencephalic porcine brain. Local application of magnesium sulfate led to a complete inhibition of spreading depolarizations. One hour after washing out the topical magnesium sulfate, re-incidence of the spreading depolarizations was observed in 50%doi:10.1177/0271678x16671317 pmid:27683450 pmcid:PMC5363671 fatcat:jz7cz6ktxjcndhgcvjv2g3kxwe