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In Vivo Kinetic and Steady-State Quantification of 18F-CPFPX Binding to Rat Cerebral A1 Adenosine Receptors: Validation by Displacement and Autoradiographic Experiments
2013
Journal of Nuclear Medicine
In vivo imaging of the A 1 adenosine receptor (A 1 AR) using 18 F-8cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine ( 18 F-CPFPX) and PET has become an important tool for studying physiologic and pathologic states of the human brain. However, dedicated experimental settings for small-animal studies are still lacking. The aim of the present study was therefore to develop and evaluate suitable pharmacokinetic models for the quantification of the cerebral A 1 AR in high-resolution PET. Methods: On
doi:10.2967/jnumed.112.115576
pmid:23740103
fatcat:bi3m6fojb5h45hh36rvamjdsnm