Inorganic nitrate supplementation attenuates peripheral chemoreflex sensitivity but does not improve cardiovagal baroreflex sensitivity in older adults

Joshua M. Bock, Kenichi Ueda, Aaron C. Schneider, William E. Hughes, Jacqueline K. Limberg, Nathan S. Bryan, Darren P. Casey
2018 American Journal of Physiology. Heart and Circulatory Physiology  
Bryan NS, Casey DP. Inorganic nitrate supplementation attenuates peripheral chemoreflex sensitivity but does not improve cardiovagal baroreflex sensitivity in older adults. Aging is associated with increased peripheral chemoreceptor activity, reduced nitric oxide (NO) bioavailability, and attenuation of cardiovagal baroreflex sensitivity (BRS), collectively increasing the risk of cardiovascular disease. Evidence suggests that NO may attenuate peripheral chemoreflex sensitivity and increase BRS.
more » ... y and increase BRS. Exogenous inorganic nitrate (NO 3 Ϫ ) increases NO bioavailability via the NO 3 Ϫ -NO 2 Ϫ -NO pathway. Our hypothesis was
doi:10.1152/ajpheart.00389.2017 pmid:28971842 fatcat:xlkwztf36fbetb5qmibflgfj7m