STIM1 Mediates Hypoxia-Driven Hepatocarcinogenesis via Interaction with HIF-1

Yongsheng Li, Bo Guo, Qichao Xie, Duyun Ye, Dongxin Zhang, Ying Zhu, Hongxiang Chen, Bo Zhu
2015 Cell Reports  
Highlights d STIM1 elevation correlates with HIF-1a during hypoxic tumor growth d HIF-1 transcripts STIM1 and promotes SOCE in hypoxic HCCs d STIM1-mediated SOCE feedforward contributes to HIF-1 accumulation in hypoxic HCCs d HIF1-STIM1 circuit orchestrates hypoxic hepatocarcinogenesis
doi:10.1016/j.celrep.2015.06.033 pmid:26166565 fatcat:jhtbojl3cvh45nmgaskkb6y37m