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Tumor Angiogenesis: Cause or Consequence of Cancer?
2007
Cancer Research
Both tumors and normal tissues need a blood supply for oxygen, nutrients, and waste removal. However, whereas normal vasculature is hierarchically assembled into efficient networks of arteries, capillaries, and veins, the blood vessels of tumors are a mess-chaotic, leaky, inefficient, and barely making do. Why the difference? Do tumor vessels lack the signals to mature or, instead, is their maturation actively suppressed? What triggers and maintains tumor vasculature? In a recent study using a
doi:10.1158/0008-5472.can-07-2053
pmid:17671171
fatcat:zkfg47vh5jbqtce6vjob4fxq2a