SYNTHESIS OF SOME CHALCONE DERIVATIVES, IN VITRO AND IN SILICO TOXICITY EVALUATION

A. N. Kristanti, H. Suwito, N.S. Aminah, K.U. Haq, H. D. Hardiyanti, H. Anggraeni, N. Faiza, R.S. Anto, S. Muharromah
2020 RASAYAN Journal of Chemistry  
Chalcone can be synthesized using some methods, but conventional Claisen-Schmidt condensation is still the best method. The objevtives of this study were to synthesize some chalcone derivatives using conventional Claisen-Schmidt condensation by reacting 2-hydroxyacetophenone and some substituted benzaldehydes using NaOH 40%, followed by evaluating their cytotoxicity in vitro against HeLa cancer cells line using MTT method and analyzing molecular docking on p53 and MDM2 interaction. Cytotoxicity
more » ... ction. Cytotoxicity test exhibited that 2,5-dimethoxy-2´hydroxychalcone and 4-chloro-2'-hydroxychalcone gave very low IC 50 , but both did not show potential apoptosis activity, while in docking analysis 4-chloro-2'-hydroxychalcone showing the best results.
doi:10.31788/rjc.2020.1315534 fatcat:diiedko66nditlnisq2swkwlsq