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A human monoclonal antibody which inhibits the coaggregation activity of Porphyromonas gingivalis
Infection and Immunity
A B-cell line producing a human monoclonal antibody (HuMAb) against a recombinant 40-kDa outer membrane protein (OMP) of Porphyromonas gingivalis was constructed by in vivo immunization of a severe combined immunodeficiency C.B.-17/Icr mouse, which had been injected with human peripheral blood lymphocytes, with recombinant 40-kDa OMP and subsequent Epstein-Barr virus immortalization of B cells isolated from the spleen of the mouse. This HuMAb inhibited coaggregation between P. gingivalis vesicles and Actinomyces naeslundii cells.doi:10.1128/iai.65.9.3966-3969.1997 fatcat:mv2dbpqx75aa7h5u56bqg4runi