Clonidine is an alpha-2-agonist that has been used in perioperative medicine for several purposes: premedication, neuraxial analgesia adjuvant to promote hemodynamic stability, anti-sialagogue and treatment of per-operative shivering. The duration of action of this drug is approximately 12 hours. Recently, anesthesiologists are being interested in the use of clonidine for labor analgesia, both as intrathecal or epidural. Primigravida, 25 years old, 38 weeks of pregnancy, requested analgesia for

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... vaginal delivery with 3cm cervical dilatation. After venous puncture, epidural interspace L4-L5 was punctured, with the loss of resistance technique. Then, 20ml of bupivacaine 0.065% with sufentanil (10µg) and clonidine (37.5µg) was Citation: de Souza Hobaika AB, da Cruz Trigueiro M, de Souza VP (2014) Late Maternal Hypotension after Administration of a Mini-Dose of Clonidine Added to sparing effect of clonidine added to ropivacaine for labour epidural analgesia. Anaesth Analg 95(3): 728-734. 6. Dewandre PY, Decurninge V, Bonhomme V, Hans P, Brichant JF (2010) Side effects of the addition of clonidine 75 microg or sufentanil 5 microg to 0.2% ropivacaine for labour epidural analgesia. Int J Obstet Anesth 19(2): 149-154. 7. Le Polain B, De Kock M, Scholtes JL, Van Lierde M (1993) Clonidine combined with sufentanil and bupivacaine with adrenaline for obstetric analgesia. Br J Anaesth 71(5): 657-660.