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Attenuation of CD4+ T-cell function by human adenovirus type 35 is mediated by the knob protein
Journal of General Virology
The complement-regulatory protein CD46 is the primary receptor for human adenovirus type 35 (HAdV-35) and can regulate human immune-cell activation. CD4 + T-cells are critical for initiating and maintaining adaptive immunity elicited by infection or vaccination. It was reported previously that HAdV-35 can bind these cells and suppress their activation. The data reported here demonstrate that recombinant trimeric HAdV-35 knob proteins alone can induce CD46 receptor downregulation and inhibitdoi:10.1099/vir.0.039222-0 pmid:22357750 fatcat:wsmltmex6fhf5kwba33gvfthhm