The use of gold nanoparticle aggregation for DNA computing and logic-based biomolecular detection

In-Hee Lee, Kyung-Ae Yang, Ji-Hoon Lee, Ji-Yoon Park, Young Gyu Chai, Jae-Hoon Lee, Byoung-Tak Zhang
2008 Nanotechnology  
The use of DNA molecules as a physical computational material has attracted much interest, especially in the area of DNA computing. DNAs are also useful for logical control and analysis of biological systems if efficient visualization methods are available. Here we present a quick and simple visualization technique that displays the results of the DNA computing process based on a colorimetric change induced by gold nanoparticle aggregation, and we apply it to the logic-based detection of
more » ... detection of biomolecules. Our results demonstrate its effectiveness in both DNA-based logical computation and logic-based biomolecular detection.
doi:10.1088/0957-4484/19/39/395103 pmid:21832585 fatcat:24tq3jg2ejbodpf5ddwbkx6uce