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Nefrotoxicidade por lítio
2010
Revista da Associação Médica Brasileira
Lithium has been widely used in the treatment of bipolar disorder. Its renal toxicity includes impaired urinary concentrating ability and natriuresis, renal tubular acidosis, tubulointerstitial nephritis progressing to chronic kidney disease and hypercalcemia. The most common adverse effect is nephrogenic diabetes insipidus, which affects 20-40% of patients within weeks of lithium initiation. Chronic nephropathy correlates with duration of lithium therapy. Early detection of renal dysfunction
doi:10.1590/s0104-42302010000500025
pmid:21152836
fatcat:ubpseqrzdfhdjlrt4zqhxqbuni