Nefrotoxicidade por lítio

Jobson Lopes de Oliveira, Geraldo Bezerra da Silva Júnior, Krasnalhia Lívia Soares de Abreu, Natália de Albuquerque Rocha, Luiz Fernando Leonavicius G Franco, Sônia Maria Holanda Almeida Araújo, Elizabeth de Francesco Daher
2010 Revista da Associação Médica Brasileira  
Lithium has been widely used in the treatment of bipolar disorder. Its renal toxicity includes impaired urinary concentrating ability and natriuresis, renal tubular acidosis, tubulointerstitial nephritis progressing to chronic kidney disease and hypercalcemia. The most common adverse effect is nephrogenic diabetes insipidus, which affects 20-40% of patients within weeks of lithium initiation. Chronic nephropathy correlates with duration of lithium therapy. Early detection of renal dysfunction
more » ... ould be achieved by rigorous monitoring of patients and close collaboration between psychiatrists and nephrologists. Recent experimental and clinical studies begin to clarify the mechanisms by which lithium induces changes in renal function. The aim of this study was to review the pathogenesis, clinical presentation, histopathological aspects and treatment of lithium-induced nephrotoxicity.
doi:10.1590/s0104-42302010000500025 pmid:21152836 fatcat:ubpseqrzdfhdjlrt4zqhxqbuni