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Histone mediated transduction for gene therapy and novel reverse transfection cell microarrays based on aminomalononitrile self-polymerisation chemistry
Our understanding of the link between gene function and disease is constantly strengthening however gene therapy is currently limited by a lack of safe, efficient and specific vectors for DNA delivery. Histone mediated transduction (HMT) is a promising, efficient non-viral DNA delivery technique utilising histone proteins as non-toxic DNA vectors. The tumour cell enhanced nuclear targeting signal (tNTS) of the Apoptin protein has been fused to histones in Chapter 2 to create novel recombinantdoi:10.4225/03/58b8af837f983 fatcat:6xc7fqsdhzd5hiytcmviy6dwn4