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Faculty of 1000 evaluation for Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes
[dataset]
2010
F1000 - Post-publication peer review of the biomedical literature
unpublished
Granulosa cells of mammalian Graafian follicles maintain oocytes in meiotic arrest, which prevents the precocious maturation. We show that mouse mural granulosa cells, which line the follicle wall, express natriuretic peptide precursor type C, Nppc, mRNA while cumulus cells surrounding oocytes express mRNA of the NPPC receptor NPR2, a guanylyl cyclase. NPPC elevated cGMP levels in cumulus cells and oocytes and inhibited meiotic resumption in vitro. Meiotic arrest was not sustained in most
doi:10.3410/f.5666956.7253054
fatcat:l3acchmzzrec7ef4rwtgjscna4