Predictive value of FDG PET/CT in pediatric Neuroblastoma patients
The Egyptian Journal Nuclear Medicine
Purpose: To explore the prognostic value of F-18 FDG PET/CT in neuroblastoma patients. Materials and method: comparative study with 63 pathologically proved NB patients with dominating high risk category (~65.1 %) who underwent F-18 FDG PET/CT using standard technique for purpose of initial, posttherapy or follow up assessment. Clinico-pathological, radiological and follow up data were also collected.Results:FDG uptake level was expressed in terms of maximum standardized uptake of the primary
... sion against the maximum standardized uptake of the reference liver activity and maximum standardized uptake of the primary lesion stands alone where ROC curves marked cut off values of 1.95 & 2.05 respectively (both are almost double the reference hepatic activity). The marked cut-off values were tested in respect to the established clinicopathological features and the disease outcome. we found significant relationship between the Shimada classification and FDG uptake level ,using 2.05 (cut-off value of the max SUV of the primary lesion), where 88.9% of those with favorable histology exhibit low FDG tumor uptake , while on the contrary 51.9 % Original article, Oncology Egyptian J. Nucl. Med., Vol. 10, No. 2, Dec 2014 CONCLUSION: PET-CT seems a valuable prognostic indicator where higher tracer accumulation of F-18 FDG seems to be linked to unfavorable histology and lower survival.