Predictive value of FDG PET/CT in pediatric Neuroblastoma patients

Mai Amr
2014 The Egyptian Journal Nuclear Medicine  
Purpose: To explore the prognostic value of F-18 FDG PET/CT in neuroblastoma patients. Materials and method: comparative study with 63 pathologically proved NB patients with dominating high risk category (~65.1 %) who underwent F-18 FDG PET/CT using standard technique for purpose of initial, posttherapy or follow up assessment. Clinico-pathological, radiological and follow up data were also collected.Results:FDG uptake level was expressed in terms of maximum standardized uptake of the primary
more » ... sion against the maximum standardized uptake of the reference liver activity and maximum standardized uptake of the primary lesion stands alone where ROC curves marked cut off values of 1.95 & 2.05 respectively (both are almost double the reference hepatic activity). The marked cut-off values were tested in respect to the established clinicopathological features and the disease outcome. we found significant relationship between the Shimada classification and FDG uptake level ,using 2.05 (cut-off value of the max SUV of the primary lesion), where 88.9% of those with favorable histology exhibit low FDG tumor uptake , while on the contrary 51.9 % Original article, Oncology Egyptian J. Nucl. Med., Vol. 10, No. 2, Dec 2014 CONCLUSION: PET-CT seems a valuable prognostic indicator where higher tracer accumulation of F-18 FDG seems to be linked to unfavorable histology and lower survival.
doi:10.21608/egyjnm.2014.5452 fatcat:pmuc7i5gpjflhnpy6zgkzttrge