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Stroke, including hemorrhagic and ischemic stroke, refers to the blood supply disorder in the local brain tissue for various reasons (aneurysm, occlusion, etc.). It leads to regional brain circulation imbalance, neurological complications, limb motor dysfunction, aphasia, and depression. As the second-leading cause of death worldwide, stroke poses a significant threat to human life characterized by high mortality, disability, and recurrence. Therefore, the clinician has to care about thedoi:10.3389/fnagi.2022.863379 pmid:35401147 pmcid:PMC8984121 fatcat:tmlpzsfumrcslfyj2zseglqr3q