Visual vs Fully Automatic Histogram-Based Assessment of Idiopathic Pulmonary Fibrosis (IPF) Progression Using Sequential Multidetector Computed Tomography (MDCT)

Davide Colombi, Julien Dinkel, Oliver Weinheimer, Berenike Obermayer, Teodora Buzan, Diana Nabers, Claudia Bauer, Ute Oltmanns, Karin Palmowski, Felix Herth, Hans Ulrich Kauczor, Nicola Sverzellati (+3 others)
2015 PLoS ONE  
Objectives To describe changes over time in extent of idiopathic pulmonary fibrosis (IPF) at multidetector computed tomography (MDCT) assessed by semi-quantitative visual scores (VSs) and fully automatic histogram-based quantitative evaluation and to test the relationship between these two methods of quantification. Methods Forty IPF patients (median age: 70 y, interquartile: 62-75 years; M:F, 33:7) that underwent 2 MDCT at different time points with a median interval of 13 months
more » ... : 10-17 months) were retrospectively evaluated. In-house software YACTA quantified automatically lung density histogram (10 th -90 th percentile in 5 th percentile steps). Longitudinal changes in VSs and in the percentiles of attenuation histogram were obtained in 20 untreated patients and 20 patients treated with pirfenidone. Pearson correlation analysis was used to test the relationship between VSs and selected percentiles.
doi:10.1371/journal.pone.0130653 pmid:26110421 pmcid:PMC4482435 fatcat:yf2be2h4jvbuxdcwdugyjmaizq