A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf
.
Microcephaly models in the developing zebrafish retinal neuroepithelium point to an underlying defect in metaphase progression
2013
Open Biology
Autosomal recessive primary microcephaly (MCPH) is a congenital disorder characterized by significantly reduced brain size and mental retardation. Nine genes are currently known to be associated with the condition, all of which encode centrosomal or spindle pole proteins. MCPH is associated with a reduction in proliferation of neural progenitors during fetal development. The cellular mechanisms underlying the proliferation defect, however, are not fully understood. The zebrafish retinal
doi:10.1098/rsob.130065
pmid:24153002
pmcid:PMC3814721
fatcat:gsoyyw6uuvgvdoe55jhli76cuu