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A Change in the Plasma Concentration of Morphine and Morphine Metabolites During Morphine Administration in Terminal Canser Patients with Renal Dysfunction
腎機能障害を合併した終末期癌患者における血中モルヒネおよびモルヒネ代謝物濃度の検討
1999
Journal of Japan Society of Pain Clinicians
腎機能障害を合併した終末期癌患者における血中モルヒネおよびモルヒネ代謝物濃度の検討
Preserved Fulltext
Plasma concentrations of morphine (MOR), morphine-3-glucuronare (M3G) and morphine -6glucuronare (M6G) were analyzed in 3 renal dysfunction patients who had received morphine. The patients showed increased plasma concentrations of MOR, and marked increases in M3G and M6G. These results indicare that MOR metabolites accumulate in plasma more easily than MOR itself in advanced cancer-related pain patients with renal dysfunction. In cancer patients with renal dysfunction, assessment of plasma
doi:10.11321/jjspc1994.6.2_100
fatcat:f5qmsvxyc5dpfpv27vshz3n234