A Change in the Plasma Concentration of Morphine and Morphine Metabolites During Morphine Administration in Terminal Canser Patients with Renal Dysfunction

Koichi OTA, Yoko TARUMI, Hiroshi MAENO, Ko HISAHARA, Eiji OWADA, Kunihiko ISHITANI, Akiyoshi NAMIKI
1999 Journal of Japan Society of Pain Clinicians  
Plasma concentrations of morphine (MOR), morphine-3-glucuronare (M3G) and morphine -6glucuronare (M6G) were analyzed in 3 renal dysfunction patients who had received morphine. The patients showed increased plasma concentrations of MOR, and marked increases in M3G and M6G. These results indicare that MOR metabolites accumulate in plasma more easily than MOR itself in advanced cancer-related pain patients with renal dysfunction. In cancer patients with renal dysfunction, assessment of plasma
more » ... ntrations of MOR and MOR metabolites is necessary determine the optimal MOR doses.
doi:10.11321/jjspc1994.6.2_100 fatcat:f5qmsvxyc5dpfpv27vshz3n234