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Dietary Soy Sphingolipids Suppress Tumorigenesis and Gene Expression in 1,2-Dimethylhydrazine-Treated CF1 Mice and ApcMin/+ Mice
2004
Journal of Nutrition
Dietary supplementation with milk sphingolipids inhibits colon tumorigenesis in CF1 mice treated with a colon carcinogen [1,2-dimethylhydrazine (DMH)] and in multiple intestinal neoplasia (Min) mice, which develop intestinal tumors spontaneously. Plant sphingolipids differ structurally from those of mammals [soy glucosylceramide (GlcCer) consists predominantly of a 4,8-sphingadiene backbone and ␣-hydroxy-palmitic acid], which might affect their bioactivity. Soy GlcCer was added to the AIN-76A
doi:10.1093/jn/134.5.1157
pmid:15113963
fatcat:ln7shqzt3jgppazmdk2tlyu2uq