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The immune system functions to protect an organism against microbial infections and may be involved in the reparative response to nerve injury. The goal of this study was to determine whether the immune system plays a role in regulating motoneuron survival after a peripheral nerve injury. After a right facial nerve axotomy, facial motoneuron (FMN) survival in C.B-17 (ϩ/ϩ) wild-type mice was found to be 87 Ϯ 3.0% of the unaxotomized left side control. In contrast, facial nerve axotomy in C.B-17doi:10.1523/jneurosci.19-11-j0004.1999 pmid:10341268 fatcat:auzw462y7jcmflsdsw4fqzvj6q