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Synthetic studies towards the development of a novel class of acitretin-type retinoids
3,4,5-Trimethoxyaniline, indole-3-carboxylic acid and the dicarboxylic acids fumaric, maleic, succinic and phthalic have been combined to produce novel analogs of the aromatic retinoid acitretin. These analogs are characterized by a highly electron-rich benzene ring in the lipophilic part and two amide bonds, replacing the C7-C8 and C11-C12 double bonds, with simultaneous restriction of the C9-C10 double bond, in the spacer compared to acitretin. In addition, the terminal trans C13-C14 doubledoi:10.3998/ark.5550190.0004.623 fatcat:7c5etfyv5ncsbeaw42x5gml2ee