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A diet-dependent enzyme from the human gut microbiome promotes Th17 accumulation and colitis
Aberrant activation of Th17 cells by the gut microbiota contributes to autoimmune and chronic inflammatory disease; however, the mechanisms responsible and their diet-dependence remain unclear. Here, we show that the disease-associated gut Actinobacterium Eggerthella lenta increases intestinal Th17 cells and worsens colitis. E. lenta-induced disease and Th17 accumulation was Rorc-dependent and strain variable. Comparative genomics revealed a single genomic locus predictive of Th17 accumulationdoi:10.1101/766899 fatcat:s3j63scvqngmhmaufka2klyuua