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The SHB Adapter Protein Is Required for Normal Maturation of Mesoderm during in Vitro Differentiation of Embryonic Stem Cells
2006
Journal of Biological Chemistry
Definitive mesoderm arises from a bipotent mesendodermal population, and to study processes controlling its development at this stage, embryonic stem (ES) cells can be employed. SHB (Src homology 2 protein in -cells) is an adapter protein previously found to be involved in ES cell differentiation to mesoderm. To further study the role of SHB in this context, we have established ES cell lines deficient for one (SHB ؉/؊ ) or both SHB alleles (SHB ؊/؊ ). Differentiating embryoid bodies (EBs)
doi:10.1074/jbc.m604084200
pmid:16971391
fatcat:yupanbzptvew5mivtepz2fiic4