Microwave-Promoted Synthesis of 4-Arylpyrimidines by Pd-Catalysed Suzuki–Miyaura Coupling of 4-Pyrimidyl Tosylates in Water

Moisés Domínguez, José Rodríguez-Aguilar, Beatriz Ordóñez, Matías Vidal, Marcos Rezende
2017 SynOpen  
The Suzuki-Miyaura coupling reaction of 4-pyrimidyl tosylates was investigated with aryl, heteroaryl and alkyl boronic acids. The reaction provided 4-substituted pyrimidines in good-to-excellent yields after one-hour microwave irradiation in water at 100 °C. The method constitutes a fast option for the synthesis of these heterocyclic systems.
doi:10.1055/s-0036-1588810 fatcat:smsk2q75zbatfcr7vd4chxivmi