Design, synthesis, and biological evaluation of AV6 derivatives as novel dual reactivators of latent HIV-1

Mingtao Ao, Zhenrui Pan, Yuqing Qian, Bowen Tang, Zeming Feng, Hua Fang, Zhen Wu, Jingwei Chen, Yuhua Xue, Meijuan Fang
2018 RSC Advances  
As dual-acting HIV LRAs, compounds 12c and 12d could activate latent HIV-1 via the NFAT-required mechanism and as histone deacetylase (HDAC) inhibitors.
doi:10.1039/c8ra01216d pmid:35539279 pmcid:PMC9080425 fatcat:o5ahbbnxfnf5zgs5kjg57otnke