Diffeomorphic registration with self-adaptive spatial regularization for the segmentation of non-human primate brains

Laurent Risser, Lionel Dolius, Caroline Fonta, Muriel Mescam
2014 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society  
Cerebral aging has been linked to structural and functional changes in the brain throughout life. Here, we study the marmoset, a small non-human primate, in order to get insights into the mechanisms of brain aging in normal and pathological conditions. Imaging the brain of small animals with techniques such as MRI, quickly becomes a challenging task when compared with human brain imaging. Very often, a simple pre-processing step such as brain extraction cannot be achieved with classical tools.
more » ... n this paper, we propose a diffeomorphic registration algorithm, which makes use of learned constraints to propagate the manual segmentation of a marmoset brain template to other MR images of marmoset brains. The main methological contribution of our paper is to explore a new strategy to automatically tune the spatial regularization of the deformations. Results show that we obtain a robust segmentation of the brain, even for images with a low contrast. 978-1-4244-7929-0/14/$26.00 ©2014 IEEE
doi:10.1109/embc.2014.6945164 pmid:25571532 dblp:conf/embc/RisserDFM14 fatcat:2empg4l2sfegxp6bp4e7bdhv2y