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ENHANCED PLATELT RELEASE REACTION, INCREASED PLATELET AGGREGATION (PA) AND PLATELET THROMBOXANE B2 (TXB2) GENERATION IN MYOTONIC DYSTROPHY
Plasma β-thromboglobulin (βTG) level, 14C 5-hydroxytryptamine (5Ht) release, PA induced by 1-epinephrine (0.2-1.0 μM) and ADP (0.5, 1.0 and 1.5 μM), and platelet TXB2 generation and eTG release after stimulation with the 2 PA inducers, was studied in platelet rich plasma of 16 patients with myotonic dystrophy (MYD) and 14 apparently healthy controls. Plasma βTG values were higher (p< 0.011) and 5Ht release was increased (p<0.035) in the patients than controls. The extent of PA induced bydoi:10.1055/s-0038-1644572 fatcat:kld7ryhawvbqhi3xpz3cqnzrjm