A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf
.
Inducible Expression of Tau Repeat Domain in Cell Models of Tauopathy
2005
Journal of Biological Chemistry
We generated several cell models of tauopathy in order to study the mechanisms of neurodegeneration in diseases involving abnormal changes of tau protein. N2a neuroblastoma cell lines were created that inducibly express different variants of the repeat domain of tau (tau RD ) when exposed to doxycycline (Tet-On system). The following three constructs were chosen: (i) the repeat domain of tau that coincides with the core of Alzheimer paired helical filaments; (ii) the repeat domain with the
doi:10.1074/jbc.m507753200
pmid:16246844
fatcat:tutxd5gdwvcenfeusyp56d2say