This study assessed the incidence of malaria and typhoid infection among adult residents in Idirokotaking from October 2020-October 2021. The study used retrospective analyses of relevant information indicating malaria and typhoid infections among adult residents in Idiroko at the health information department of the state hospital, Idiroko, Ogun State. The data were analyzed statistically and the empirical values were represented. One thousand and eight hundred and ten cases of incidence of

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... aria, typhoid and their co-infection were extracted for the study, 601(33.2%) cases indicated for malaria only, 433(23.9%) cases for typhoid only and 776 (42.9%) cases had an incidence of malaria and typhoid as co-infections. There is no significant association between increasing age and positivity to the malaria parasite in this study. Female respondents 341(18.8%) were more infected with malaria parasite than the males 260(14.4%) as elucidated by the study. Although the difference observed was not statistically significant. A high prevalence (24%) of Salmonella typhi infections was recorded and the study showed an infection rate was higher in females 322(17.6%) than males 111(6.1%). In comparison, malaria and typhoid as co-infection were higher in females 539(29.8%) than males 237(13.1%). In conclusion, the incidence of malaria and typhoid infection and, co-infection among the adult residents in the Idiroko area of Ogun State is significantly high. To reduce the incidence of typhoid fever and malaria as co-infection, it is necessary to discourage people from taking junk food, maintain adequate personal, and environmental sanitation and prevent mosquito bites through the use of the medicated net.