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Precision Medicine for Sickle Cell Disease: Discovery of Genetic Targets for Drug Development
[chapter]
2016
Sickle Cell Disease - Pain and Common Chronic Complications
Sickle cell disease (SCD) consists of inherited monogenic hemoglobin disorders affecting over three million people worldwide. Efforts to establish precision medicine based on the discovery of genetic polymorphisms associated with disease severity are ongoing to inform strategies for novel drug design. Numerous gene mutations have been associated with the clinical complications of SCD such as frequency of pain episodes, acute chest syndrome, and stroke among others. However, these discoveries
doi:10.5772/64817
fatcat:wmc75djbyvgybkcxzr42azmz7u