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Activation of Gαiand Subsequent Uncoupling of Receptor-GαiSignaling byPasteurella multocidaToxin
2008
Journal of Biological Chemistry
Bacterial protein toxins are powerful tools for elucidating signaling mechanisms in eukaryotic cells. A number of bacterial protein toxins, e.g. cholera toxin, pertussis toxin (PTx), or Pasteurella multocida toxin (PMT), target heterotrimeric G proteins and have been used to stimulate or block specific signaling pathways or to demonstrate the contribution of their target proteins in cellular effects. PMT is a major virulence factor of P. multocida causing pasteurellosis in man and animals and
doi:10.1074/jbc.m803435200
pmid:18583341
fatcat:ru2r3dxm6zatbkhb7fmrzuq5oy