Poly ADP-ribosylation: a histone shuttle mechanism in DNA excision repair

F R Althaus
1992 Journal of Cell Science  
In DNA excision repair of mammalian cells, the processing of ADP-ribose by the poly ADP-ribosylation system of chromatin is stimulated several thousand-fold. Most of this turnover is associated with the automodification reaction of the nuclear enzyme poly(ADP-ribose) polymerase and the degradation of polymerase-bound polymers by the enzyme poly(ADP-ribose) glycohydrolase. The automodification cycle catalyzes a temporary dissociation from and reassociation of histones with DNA. It is proposed
more » ... . It is proposed that this mechanism, termed "histone shuttle", may guide specific proteins to sites of repair. In addition, histone shuttling driven by the poly ADP-ribosylation system seems to be involved in nucleosomal unfolding of chromatin in DNA excision repair.
pmid:1429884 fatcat:vqdzgq4tnjdvnccpvty3b7jtyu