Synthesis and Preliminary Biological Evaluations of 5′-Substituted Derivatives of Uridine as Glycosyltransferase Inhibitors

Jadwiga Paszkowska, Katarzyna Kral, Tadeusz Bieg, Urszula Nawrot, Wiesław Szeja, Ilona Wandzik
2013 Molecules  
New derivatives of uridine which contain a β-ketoenol motif were synthesized, characterized and biologically tested. Synthesized compounds 1-4 showed no activity against bovine milk β-1,4-galactosyltransferase I at concentrations up to 2.0 mM and were not active against Candida albicans and Aspergilus fumigatus up to the maximum tested concentration of 1,000 µg/mL.
doi:10.3390/molecules18078018 pmid:23884133 fatcat:ine724a6jzee7p74vkmo522gxi