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A transient disruption of fibroblastic transcriptional regulatory network facilitatestrans-differentiation
2014
Nucleic Acids Research
Transcriptional Regulatory Networks (TRNs) coordinate multiple transcription factors (TFs) in concert to maintain tissue homeostasis and cellular function. The re-establishment of target cell TRNs has been previously implicated in direct trans-differentiation studies where the newly introduced TFs switch on a set of key regulatory factors to induce de novo expression and function. However, the extent to which TRNs in starting cell types, such as dermal fibroblasts, protect cells from undergoing
doi:10.1093/nar/gku567
pmid:25013174
pmcid:PMC4132712
fatcat:fd7zhl2zobgzbcklk3uexn4ujq