Histomorphological study with nerve sheath differentiation

Thahseena Abdulla, Prema Saldanha
2016 MedPulse-International Medical Journal   unpublished
The malignant peripheral nerve sheath tumour (MPNST) is a rare and aggressive sarcoma that arises from the peripheral nerve sheath, and displays differentiation along the nerve sheath components. Since it exhibits varying growth patterns, and is associate descriptive study of cases from the archives of our Pathology Department. The clinical details were obtained from the hospital records. A detailed histopathological study was done wherever required. Tumours were graded using the FNCLCC system.
more » ... the FNCLCC system. peripheral nerve sheath tumours were found. The age of the patients ranged from 14 to 75 y female ratio of 1.2:1. There were five cases in the thigh and buttock region, three cases from the spinal region, two cases from intraabdominal region, one case from the distal end of lower limb, and one case each from the for The tumour size ranged from 1.5 cms to 18 cms. Microscopically, the tumours showed varied growth patterns and features of malignancy. All the tumours were S most difficult among the soft tissue tumours because of the lack of standardized diagnostic criteria. The poor prognosis coupled with its varied presentation necessitates an early diagnosis. Immunohistochemistry may be required for confirmation of the diagnosis.
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