The Most Negatively Charged Low-Density Lipoprotein L5 Induces Stress Pathways in Vascular Endothelial Cells

Ching-Yi Chen, Hsiu-Ching Hsu, An-Sheng Lee, Daming Tang, Lu-Ping Chow, Chao-Yuh Yang, Han Chen, Yuan-Teh Lee, Chu-Huang Chen
2012 Journal of Vascular Research  
one proteins ORP150, Grp94, and Grp58, mitochondrial proteins Prdx3 and ATP synthase, and an increase in the expression of the pro-inflammatory protein hnRNP C1/C2. Conclusions: Our work suggests that L5, but not L1, may promote the destruction of ECs that occurs during atherogenesis by causing mitochondrial dysfunction and modulating the expression of key proteins to promote inflammation, ER dysfunction, oxidative stress, and apoptosis.
doi:10.1159/000337463 pmid:22627396 fatcat:rgbi4aea6bcj7g7edts6klf2wi