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Dynamic Transition States of ErbB1 Phosphorylation Predicted by Spatial Stochastic Modeling
2013
Biophysical Journal
ErbB1 overexpression is strongly linked to carcinogenesis, motivating better understanding of erbB1 dimerization and activation. Recent single-particle-tracking data have provided improved measures of dimer lifetimes and strong evidence that transient receptor coconfinement promotes repeated interactions between erbB1 monomers. Here, spatial stochastic simulations explore the potential impact of these parameters on erbB1 phosphorylation kinetics. This rule-based mathematical model incorporates
doi:10.1016/j.bpj.2013.07.056
pmid:24048005
pmcid:PMC3785885
fatcat:pbkpm4hszbeuvbznglsqnnea24