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Importance of Homodimerization for thein VivoFunction of Yeast RNA Triphosphatase
2001
Journal of Biological Chemistry
Saccharomyces cerevisiae RNA triphosphatase Cet1 is an essential component of the yeast mRNA capping apparatus. The active site of Cet1 resides within a topologically closed hydrophilic -barrel (the triphosphate tunnel) that is supported by a globular hydrophobic core. The homodimeric quaternary structure of Cet1 is formed by a network of contacts between the partner protomers. By studying the effects of alanine-cluster mutations, we highlight the contributions of two separate facets of the
doi:10.1074/jbc.m100588200
pmid:11279098
fatcat:jqrvryxhdbckfi2roxemcz3bku