Intraoperative high-field magnetic resonance imaging combined with functional neuronavigation in resection of low-grade temporal lobe tumors

Shao-cong Bai, Bai-nan Xu, Shi-hui Wei, Jie-feng Geng, Dong-dong Wu, Xin-guang Yu, Xiao-lei Chen
2015 World Journal of Surgical Oncology  
The aim of this study is to investigate the role of intraoperative MR imaging in temporal lobe lowgrade glioma (LGG) surgery and to report the surgical outcome in our series with regard to seizures, neurological defects, and quality of life. Methods: Patients with temporal lobe contrast-nonenhancing gliomas who presented with seizures in the course of their disease were enrolled in our prospective study. We non-randomly assigned patients to undergo intraoperative magnetic resonance imaging
more » ... )-guided surgery or conventional surgery. Extent of resection (EOR) and surgical outcomes were compared between the two groups. Results: Forty-one patients were allocated in the iMRI group, and 14 were in the conventional group. Comparable EOR was achieved for the two groups (p = 0.634) although preoperative tumor volumes were significantly larger for the iMRI group. Seizure outcome tended to be better for the iMRI group (Engel class I achieved for 89.7 % (35/39) vs 75 % (9/12)) although this difference was not statistically different. Newly developed neurological deficits were observed in four patients (10.3 %) and two patients (16.7 %), respectively (p = 0.928). Free of seizures and neurological morbidity led to a return-to-work or return-to-school rate of 84.6 % (33/39) vs 75 % (9/12), respectively (p = 0.741). Conclusions: Our study provided evidence that iMRI was a safe and useful tool in temporal lobe LGG surgery. Optimal extent of resection contributed to favorable seizure outcome in our series with low morbidity rate, which led to a high return-to-work rate.
doi:10.1186/s12957-015-0690-7 pmid:26410079 pmcid:PMC4583990 fatcat:mlloah6bvbdjjmjnjo4fclccgy