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Endoglucanase activity at a second site in Pyrococcus furiosus triosephosphate isomerase-Promiscuity or compensation for a metabolic handicap?
2017
FEBS Open Bio
The eight-stranded (b/a) 8 barrel fold known as the Triosephosphate isomerase (TIM) barrel is the most commonly observed fold in enzymes, displaying an eightfold structural symmetry. The sequences and structures of different TIM barrel enzymes suggest that nature exploits the modularity inherent in the eightfold symmetry to generate enzymes with diverse enzymatic activities and, in certain cases, more than one catalytic activity per enzyme. Here, we report the discovery, verification, and
doi:10.1002/2211-5463.12249
pmid:28781953
pmcid:PMC5537068
fatcat:lqtat2k6ordfvfyktjin2uhs2e