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SUN and Lamin B proteins contribute to heterochromatin maintenance at the nuclear periphery
The majority of the human genome contains transcriptionally inactive heterochromatin and only 20% actively transcribed euchromatin. The epigenetic landscape of heterochromatin and euchromatin is different and marked by defined modifications. In order to promote heritable transmission of gene expression states, epigenetic modifications have to be faithfully restored after cell division. Except for DNA methylation, the mechanisms involved in recapitulating the parental chromatin structure aredoi:10.25365/thesis.55255 fatcat:zqjfxyinmbgrdgf7bbkmpyncvm