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How Does Proteinuria Cause Progressive Renal Damage?
Journal of the American Society of Nephrology
The possibility that proteinuria may accelerate kidney disease progression to end-stage renal failure has received support from the results of increasing numbers of experimental and clinical studies. Evidence indicating that this process occurs through multiple pathways, including induction of tubular chemokine expression and complement activation that lead to inflammatory cell infiltration in the interstitium and sustained fibrogenesis, is reviewed. Macrophages are prominent in thedoi:10.1681/asn.2006040377 pmid:17035611 fatcat:b2f7o3vgv5bqrjina4owfvxt5u